Publications
2023
Giles ED, Purcell SA, Olson J, Vrieling A, Hirko KA, Woodruff K, Playdon MC, Thomas GA, Gilmore LA, Moberly HK, Newell-Fugate AE. Trends in Diet and Cancer Research: A Bibliometric and Visualization Analysis. Cancers (Basel). 2023 Jul 25;15(15):3761. doi: 10.3390/cancers15153761.
Sanchez L, Epps J, Wall S, McQueen C, Pearson SJ, Scribner K, Wellberg EA, Giles ED, Rijnkels M, Porter WW. SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Cell Death Differ. 2023 Jun;30(6):1472-1487. doi: 10.1038/s41418-023-01146-9.
2022
Wellberg EA, Corleto KA, Checkley LA, Jindal S, Johnson G, Higgins JA, Obeid S, Anderson SM, Thor AD, Schedin PJ, MacLean PS, Giles ED. Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. Breast Cancer Res. 2022 Jun 20;24(1):42. doi: 10.1186/s13058-022-01535-x.
Kotta AS, Kelling AS, Corleto KA, Sun Y, Giles ED. Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression. Biomolecules. 2022 Mar 22;12(4):483. doi: 10.3390/biom12040483.
Baine RE, Johnston DT, Strain MM, Henwood MK, Davis JA, Reynolds JA, Giles ED, Grau JW. Noxious Stimulation Induces Acute Hemorrhage and Impairs Long-Term Recovery after Spinal Cord Injury (SCI) in Female Rats: Evidence Estrous Cycle May Have a Modulatory Effect. Neurotrauma Rep. 2022 Jan 31;3(1):70-86. doi: 10.1089/neur.2021.0055.
2021
Schembre SM, Jospe MR, Giles ED, Sears DD, Liao Y, Basen-Engquist KM, Thomson CA. A Low-Glucose Eating Pattern Improves Biomarkers of Postmenopausal Breast Cancer Risk: An Exploratory Secondary Analysis of a Randomized Feasibility Trial. Nutrients. 2021 Dec 16;13(12):4508. doi: 10.3390/nu13124508.
Glenny EM, Coleman MF, Giles ED, Wellberg EA, Hursting SD. Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer. Annu Rev Nutr. 2021 Oct 11;41:253-282. doi: 10.1146/annurev-nutr-120420-032437.
Fabian CJ, Klemp JR, Marchello NJ, Vidoni ED, Sullivan DK, Nydegger JL, Phillips TA, Kreutzjans AL, Hendry B, Befort CA, Nye L, Powers KR, Hursting SD, Giles ED, Hamilton-Reeves JM, Li B, Kimler BF. Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors. Cancers (Basel). 2021 Sep 28;13(19):4871. doi: 10.3390/cancers13194871.
Fabian CJ, Befort CA, Phillips TA, Nydegger JL, Kreutzjans AL, Powers KR, Metheny T, Klemp JR, Carlson SE, Sullivan DK, Zalles CM, Giles ED, Hursting SD, Hu J, Kimler BF. Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo. Cancer Prev Res (Phila). 2021 Sep;14(9):893-904. doi: 10.1158/1940-6207.CAPR-20-0656.
2020
Giles ED, Wellberg EA. Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools. J Mammary Gland Biol Neoplasia. 2020 Dec;25(4):237-253. doi: 10.1007/s10911-020-09463-2. Epub 2020 Nov 4. PMID: 33146844; PMCID: PMC8197449.
2019
Sherk VD, Jackman MR, Higgins JA, Giles ED, Foright RM, Presby DM, Carpenter RD, Johnson GC, Oljira R, Houck JA, Maclean PS. Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health Post-Ovariectomy. Med Sci Sports Exerc. 2019 Dec;51(12):2465-2473. doi: 10.1249/MSS.0000000000002082. PMID: 31274683; PMCID: PMC7194137.
Presby DM, Checkley LA, Jackman MR, Higgins JA, Jones KL, Giles ED, Houck JA, Webb PG, Steig AJ, Johnson GC, Rudolph MC, MacLean PS. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1;317(5):R684-R695. doi: 10.1152/ajpregu.00074.2019. Epub 2019 Sep 25. PMID: 31553623; PMCID: PMC6879845
Giles ED, Brown IL, MacLean PS, Pan Z, Melanson EL, Heard KJ, Cornier MA, Marden T, Higgins JA. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019 Oct 16;11(10):2484. doi: 10.3390/nu11102484. PMID: 31623184; PMCID: PMC6835355.
2018
Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018 Jun 14;20(1):50. doi: 10.1186/s13058-018-0974-2. PMID: 29898754; PMCID: PMC6000949.
2017
Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Horm Cancer. 2017 Dec;8(5-6):269-285. doi: 10.1007/s12672-017-0302-9. Epub 2017 Jul 24. PMID: 28741260; PMCID: PMC6022404.
Sherk VD, Jackman MR, Giles ED, Higgins JA, Foright RM, Presby DM, Johnson GC, Houck JA, Houser JL, Oljira R, MacLean PS. Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function. Physiol Rep. 2017 May;5(10):e13272. doi: 10.14814/phy2.13272. PMID: 28533263; PMCID: PMC5449558.
Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, Maclean PS. Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training. Med Sci Sports Exerc. 2017 May;49(5):888-895. doi: 10.1249/MSS.0000000000001194. Erratum in: Med Sci Sports Exerc. 2019 Nov;51(11):2428. PMID: 28079706; PMCID: PMC5392148.
Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS. Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo. Cancer Prev Res (Phila). 2017 Mar;10(3):198-207. doi: 10.1158/1940-6207.CAPR-16-0211-T. Epub 2017 Feb 2. PMID: 28154203; PMCID: PMC5405741.
2016
Giles ED, Jackman MR, MacLean PS. Modeling Diet-Induced Obesity with Obesity-Prone Rats: Implications for Studies in Females. Front Nutr. 2016 Nov 24;3:50. doi: 10.3389/fnut.2016.00050. PMID: 27933296; PMCID: PMC5121240.
Giles ED, Hagman J, Pan Z, MacLean PS, Higgins JA. Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats. Nutr Metab (Lond). 2016 Mar 1;13:18. doi: 10.1186/s12986-016-0077-y. PMID: 26937246; PMCID: PMC4773993.
Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Lindstrom RC, MacLean PS. Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol. 2016 Feb 10;7:32. doi: 10.3389/fphys.2016.00032. PMID: 26903882; PMCID: PMC4748045.
2013
Martinson HA, Lyons TR, Giles ED, Borges VF, Schedin P. Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention. Exp Cell Res. 2013 Jul 1;319(11):1671-8. doi: 10.1016/j.yexcr.2013.04.018. Epub 2013 May 9. PMID: 23664839; PMCID: PMC3980135.
2012
Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Res. 2012 Dec 15;72(24):6490-501. doi: 10.1158/0008-5472.CAN-12-1653. Epub 2012 Dec 7. PMID: 23222299; PMCID: PMC4010325.
2011
Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, MacLean PS. Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain. Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R656-67. doi: 10.1152/ajpregu.00212.2011. Epub 2011 Jun 29. PMID: 21715696; PMCID: PMC3174759.
2010
Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS. Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1634-42. doi: 10.1152/ajpregu.00219.2010. Epub 2010 Oct 6. PMID: 20926768; PMCID: PMC3007190.
2019
MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman MR, Shroyer KR, Schedin PJ. A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. Obesity (Silver Spring). 2010 Apr;18(4):696-703. doi: 10.1038/oby.2009.307. Epub 2009 Oct 1. PMID: 19798068; PMCID: PMC4973619.
MacLean PS, Higgins JA, Wyatt HR, Melanson EL, Johnson GC, Jackman MR, Giles ED, Brown IE, Hill JO. Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R793-802. doi: 10.1152/ajpregu.00192.2009. Epub 2009 Jul 8. PMID: 19587114; PMCID: PMC2739786.
2004
Rankin SL, Partlow GD, McCurdy RD, Giles ED, Fisher KR. The use of proliferating cell nuclear antigen immunohistochemistry with a unique functional marker to detect postnatal neurogenesis in paraffin-embedded sections of the mature pig brain. Brain Res Brain Res Protoc. 2004 Jun;13(2):69-75. doi: 10.1016/j.brainresprot.2004.01.002. PMID: 15171988.
2003
Rankin SL, Partlow GD, McCurdy RD, Giles ED, Fisher KR. Postnatal neurogenesis in the vasopressin and oxytocin-containing nucleus of the pig hypothalamus. Brain Res. 2003 May 9;971(2):189-96. doi: 10.1016/s0006-8993(03)02350-3. PMID: 12706235.
Giles ED, Singh G. Role of insulin-like growth factor binding proteins (IGFBPs) in breast cancer proliferation and metastasis. Clin Exp Metastasis. 2003;20(6):481-7. doi: 10.1023/a:1025854931796. PMID: 14598881.